Validation and modification of staging Systems for Poorly Differentiated Pancreatic Neuroendocrine Carcinoma
نویسندگان
چکیده
منابع مشابه
Metastatic pancreatic poorly differentiated neuroendocrine carcinoma: current treatment considerations.
Pancreatic poorly differentiated neuroendocrine tumors (PDNETs) are a subtype of neuroendocrine tumors (NETs) that are clinically distinguished by their very rapid growth. They are immunohistochemically diagnosed by having a higher Ki-67 cancer cell staining percentage when compared with well or intermediately differentiated NETs. These tumors are typically treated in the same manner as small c...
متن کاملTreatment of poorly differentiated neuroendocrine carcinoma of the pancreas.
Poorly differentiated neuroendocrine carcinoma is a rare malignancy that remains a challenge to treat. Poorly differentiated neuroendocrine carcinoma occurs at an incidence of 2% annually in United States. The current standard of care is based largely upon retrospective data. There remains a need for large prospective cooperative group trials in the management of poorly differentiated neuroendo...
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Pancreatic neuroendocrine tumors (NETs), including poorly differentiated carcinomas (NECs), are rarely encountered. The majority of these tumors do not secrete excess hormones, but functioning NETs produce large amounts of vasoactive peptides and may cause carcinoid syndrome. Synthetic somatostatin analogs (SSAs) have been widely used in NETs for control of hormonal syndromes. Here, we present ...
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The production of serotonin (5-hydroxtryptamine) and certain related metabolites by tumours associated with the clinical carcinoid syndrome has now been well established. Many of the reported cases have concerned carcinoid tumours of the intestinal tract (Thorson, 1958 ; Macfarlane, Dalgliesh, Dutton, Lennox, Nyhus, and Smith, 1956) but tumours histologically resembling carcinoids, and also app...
متن کاملIdentification and Characterization of Poorly Differentiated Invasive Carcinomas in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis
Pancreatic neuroendocrine tumors (PanNETs) are a relatively rare but clinically challenging tumor type. In particular, high grade, poorly-differentiated PanNETs have the worst patient prognosis, and the underlying mechanisms of disease are poorly understood. In this study we have identified and characterized a previously undescribed class of poorly differentiated PanNETs in the RIP1-Tag2 mouse ...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2020
ISSN: 1471-2407
DOI: 10.1186/s12885-020-6634-9